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Atazor®

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Atazor®

Atazor® is an anti-retroviral drug indicated for the treatment of HIV-1infection in patients older than 6 years (weighing at least 15 kg). Like other protease inhibitors, Atazor® is used only in association with other HIV medications. Atazor® is not a cure of HIV or AIDS.

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Approximate Delivery Date:
December, 10 - December, 19
Approximate Delivery Date:
November, 27 - December, 03

In Stock

Atazor® 300 mg; 30 caps bottle

1 bottle
£153.07 per bottle
£153.07 £191.34 per bottle
2 bottles
£149.90 per bottle
£299.79 £374.74 per 2 bottles
£299.79 Add to Basket You Save: £6.34
3 bottles
£146.72 per bottle
£440.17 £550.22 per 3 bottles
£440.17 Add to Basket You Save: £19.03
4 bottles
£145.53 per bottle
£582.14 £727.67 per 4 bottles
£582.14 Add to Basket You Save: £30.14
5 bottles
£144.82 per bottle
£724.10 £905.13 per 5 bottles
£724.10 Add to Basket You Save: £41.24

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General Info

Atazor® is an anti-retroviral drug indicated for the treatment of HIV-1infection in patients older than 6 years (weighing at least 15 kg). Like other protease inhibitors, Atazor® is used only in association with other HIV medications. Atazor® is not a cure of HIV or AIDS.

Atazor®
Active Ingredient

Atazanavir.

Description

Atazor® is manufactured by Emcure Pharmaceuticals. The raw material is Atazanavir – an anti-retroviral drug belonging to the protease inhibitor (PI) class. Atazanavir differs from other PIs in that it can be given once per day (rather than requiring multiple doses per day) and has fewer effects on the patient's lipid profile (cholesterol levels and other fatty substances in blood).

Indications:

- treatment of HIV type 1 infection in combination with low dose Ritonavir in adults and pediatric patients 6 years of age and older.

MOA (mechanism of action):

Atazanavir is an azapeptide HIV-1 protease inhibitor (PI). Atazanavir selectively inhibits the virus-specific processing of viral Gag-Pol proteins in HIV-1 infected cells, thus averting formation of mature virions and infection of other cells. Atazanavir is not active against HIV-2.

Dosage

The recommended standard treatment is Atazor® alongside Ritonavir, which ensures optimal pharmacokinetic parameters and level of virologic suppression.

Atazor® capsules must be taken with Ritonavir and have to be taken with food.

The capsules should be swallowed whole.

Adults:

The recommended dose is 300 mg with Ritonavir 100 mg taken once daily with food.

Children 6-18 years (weighing at least 15 kg):

The recommended dose is based on body weight and should not exceed the recommended adult dose.

15-35 kg: 200 mg with Ritonavir 100 mg.

35 kg and more: 300 mg with Ritonavir 100 mg.

Pediatric patients at least 3 months of age and weighing at least 5 kg are given Atazanavir oral powder.

The withdrawal of Ritonavir from the Atazor® therapy is not recommended, but may be considered in adults at the dose of 400 mg once daily with food only under the following combined restrictive conditions: absence of prior virologic failure, undetectable viral load during the last 6 months under current regimen, viral strains not harbouring HIV resistance-associated mutations (RAMs) to current regimen.

Precautions:

HIV can be transmitted through sexual contact with HIV positive partner, blood (e.g., sharing needles, handling blood instruments, receiving blood transfusions, blood products, or organ/tissue transplants that were infected with HIV), childbirth, toiletries (razors and toothbrushes). Therefore, both HIV-positive and HIV-negative individuals are advised to have any kind of sex using a latex or polyurethane condom, avoid sharing needles or other things like toothbrushes or razors. It is important to discuss with doctor the precautions needed to avoid infecting other people as well as take precautions not to get infected.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Some people who take Atazor® may experience:

- An increase in weight and in levels of blood lipids and glucose.

- Cholelithiasis (the formation of gallstones).

- Chronic kidney disease in HIV-infected patients. Regular monitoring of the renal function of patients should be maintained.

- Nephrolithiasis, that is associated with acute renal failure or renal insufficiency.

- Immune reactivation syndrome (severe immune deficiency during combination anti-retroviral therapy (CART) may lead to arousal of opportunistic infections and cause serious clinical conditions).

- Osteonecrosis (the death of bone tissue). Patients should seek medical advice if they experience joint aches and pain, joint stiffness or difficulty in movement.

- Rash and associated syndromes (mild-to-moderate maculopapular skin eruptions occurring within the first 3 weeks of starting therapy with Atazor®. Patients should seek medical advice if such signs and symptoms occur and should be monitored for skin reactions.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose of Atazor® to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store Atazor® tablets or oral powder at room temperature between 68-77 degrees F (20-25 degrees C). Keep Atazor® in the original container. Do not use Atazor® if the seal over the bottle opening is broken or missing. Keep the bottle tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Safety Information

Side effects

Common and uncommon side effects associated with Atazor® are:

  • headache
  • vomiting
  • diarrhoea
  • abdominal pain
  • nausea
  • dyspepsia
  • fatigue (extreme tiredness)
  • peripheral neuropathy
  • allergic reaction
  • asthenia
  • weight decreased
  • weight gain
  • depression
  • disorientation
  • amnesia
  • dizziness
  • somnolence (sleepiness)
  • abnormal dream
  • syncope
  • hypertension
  • dyspnoea
  • pancreatitis
  • gastritis
  • stomatitis
  • aphthous
  • dysgeusia
  • flatulence
  • angioedema
  • alopecia
  • pruritus
  • muscle atrophy
  • arthralgia
  • myalgia
  • interstitial nephritis
  • pollakiuria
  • gynaecomastia
  • chest pain
  • malaise
  • fever
  • insomnia

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Atazor® is contraindicated in patients who are allergic to Atazanavir or any of the other ingredients of Atazor®.

Do not use Atazor® in patients younger than 6 years (weight under 15 kg).

Atazor® is contraindicated in patients with severe hepatic insufficiency.

Atazor® with ritonavir is contraindicated in patients with moderate hepatic insufficiency.

Do not take Atazor® with simvastatin or lovastatin, rifampicin, PDE5 inhibitors, substrates of the CYP3A4 isoform of cytochrome P450 (quetiapine, alfuzosin, astemizole, terfenadine, cisapride, pimozide, quinidine), ergot alkaloids (ergotamine, dihydroergotamine, ergonovine, methylergonovine), products containing St. John’s wort,atorvastatin, other anti-retrovirals (NNRTI) like nevirapine or efavirenz, salmeterol, proton pump inhibitors, hormonal contraceptives etc.

Do not take Atazor® with Ritonavir at doses greater than 100 mg per day. The use of higher Ritonavir doses may alter the safety Atazanavir (cardiac effects, hyperbilirubinemia).

Concomitant administration of Voriconazole and Atazor® and Ritonavir is not recommended.

Do not take Atazor®/Ritonavir with glucocorticoids (fluticasone).

Do not take Atazor® if you have chronic hepatitis B or C.

Atazor® should be used with particular caution in association with medicinal products which can increase the QT interval and/or in patients with pre-existing risk factors (bradycardia, long congenital QT, electrolyte imbalances.

Atazor® should be used with particular caution in hemophiliac patients due to the possibility of increased bleeding.

Do not have any kind of sex without using a latex or polyurethane condom.

Do not share needles or other things like toothbrushes or razors.

Do not take Atazor® if you are pregnant or plan to have a baby without prior consulting with your healthcare provider.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Delivery Information
Destination Service Tracking Delivery Time Price
Worldwide Not trackable 14-21 working days £15.11 per order
Trackable, where available 5-9 working days £22.66 per order

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Atazor®

Atazor®

Atazor® is an anti-retroviral drug indicated for the treatment of HIV-1infection in p...

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